製品の概要

  • 製品名Recombinant Human COPS8 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q99627
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMPVAVMAESAFSFKKLLDQCENQELEAPGG IATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQR IWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIA DDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFI PLSEPAPVPPIPNEQQLARLTDYVAFLEN
    • 分子量25 kDa including tags
    • 領域1 to 209
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 10% Glycerol, 2.4% Urea, 0.32% Tris HCl

関連情報

  • 別名
    • COP9 homolog
    • COP9 signalosome complex subunit 8
    • COP9 signalosome subunit 8
    • Cops8
    • CSN8
    • CSN8_HUMAN
    • hCOP9
    • JAB1 containing signalosome subunit 8
    • JAB1-containing signalosome subunit 8
    • SGN8
    • Signalosome subunit 8
    see all
  • 機能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 配列類似性Belongs to the CSN8 family.
    Contains 1 PCI domain.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human COPS8 protein 画像

  • 15% SDS-PAGE showing ab113601 (3 µg) at approximately 25.3 kDa.

Recombinant Human COPS8 protein (ab113601) 使用論文

ab113601 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"