Recombinant Human Contactin 6 protein (ab109345)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来HEK 293 cells
  • アミノ酸配列
    • アクセッション番号Q9UQ52
    • 生物種Human
    • 分子量150 kDa including tags
    • 領域1 to 999

関連製品

特性

Our Abpromise guarantee covers the use of ab109345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Induces Hes-1 in 3T3L-1 cells.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • エンドトキシン・レベル< 0.100 Eu/µg
  • 精製度> 90 % SDS-PAGE.
    ab109345 is an 0.2 µm filtered solution.
  • 製品の状態Liquid
  • 備考 Induces Hes-1 in 3T3L-1 cells.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

関連情報

  • 別名
    • CNTN 6
    • CNTN6
    • CNTN6_HUMAN
    • Contactin 6 precursor
    • Contactin-6
    • Contactin6
    • hNB 3
    • hNB-3
    • hNB3
    • MGC133256
    • NB 3
    • NB3
    • Neural adhesion molecule
    • Neural recognition molecule NB 3
    • Neural recognition molecule NB-3
    see all
  • 機能Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
  • 組織特異性Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
  • 配列類似性Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • 細胞内局在Cell membrane.
  • Information by UniProt

Recombinant Human Contactin 6 protein 画像

  • Induction of Hes-1 with the treatment of hContactin-6-Fc.
    A Mouse preadpipocyte cell line, 3T3L1, was stimulated with 5 µg/ml of ab109345 as in indicated time points and each cell lysate was prepared and subjected to Western blot by using anti-Mouse Hes-1 or GAPDH (loading control).

    Lane M: Marker
    Lane 1: ab109345, 0 minutes
    Lane 2: ab109345, 10 minutes
    Lane 3: ab109345, 30 minutes
    Lane 4: ab109345, 1 h
    Lane 5: ab109345, 2 h
    Lane 6: ab109345, 4 h
    Lane 7: ab109345, 8 h
    Lane 8: ab109345, 24 h

Recombinant Human Contactin 6 protein (ab109345) 使用論文

ab109345 has not yet been referenced specifically in any publications.

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