Recombinant Human Constitutive androstane receptor protein (ab83193)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab83193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性1 unit equals 1 nanogram of purified protein.
  • アプリケーション

    Functional Studies

  • 製品の状態Liquid
  • 備考1 unit equals 1 nanogram of purified protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

関連情報

  • 別名
    • CAR
    • CAR BETA
    • CAR1
    • CARA
    • Constitutive activator of retinoid response
    • constitutive active receptor
    • Constitutive active response
    • constitutive androstane nuclear receptor variant 2
    • constitutive androstane nuclear receptor variant 3
    • constitutive androstane nuclear receptor variant 4
    • constitutive androstane nuclear receptor variant 5
    • Constitutive androstane receptor
    • MB67
    • MGC97144
    • NR1I3
    • NR1I3_HUMAN
    • Nuclear receptor subfamily 1 group I member 3
    • orphan nuclear hormone receptor
    • Orphan nuclear receptor MB67
    • Orphan nuclear receptor NR1I3
    see all
  • 機能Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
  • 組織特異性Predominantly expressed in liver.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
  • 翻訳後修飾Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
  • 細胞内局在Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7.
  • Information by UniProt

Recombinant Human Constitutive androstane receptor protein (ab83193) 使用論文

ab83193 has not yet been referenced specifically in any publications.

Product Wall

The tag is on the N-terminus and there is a thrombin cleavage site between the tag and the protein.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"