製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Saccharomyces cerevisiae
  • アミノ酸配列
    • 生物種Human
    • 配列MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVT TVDMTRKP EELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPR YPHLSPKYKESFDVGCNL FAKFSAYIKNTQKEANKNFEKSLLKEFKRL DDYLNTPLLDEIDPDSAEEPPVSRRLFL DGDQLTLADCSLLPKLNIIK VAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPED KEIENTYANV AKQKS

特性

Our Abpromise guarantee covers the use of ab88002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab88002 was purified by affinity chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

関連情報

  • 別名
    • Chloride intracellular channel 2
    • Chloride intracellular channel protein 2
    • CLIC 2b
    • CLIC2
    • CLIC2_HUMAN
    • CLIC2b
    • MRXS32
    • OTTHUMP00000196471
    • XAP 121
    • XAP121
    see all
  • 機能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
  • 組織特異性Detected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle.
  • 配列類似性Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • ドメインMembers of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • 細胞内局在Cytoplasm. Membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt

Recombinant Human CLIC2 protein (ab88002) 使用論文

ab88002 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"