製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号O00299
    • 生物種Human
    • 配列GSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
    • 分子量29 kDa including tags
    • 領域1 to 241
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab119166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab119166 is purified by standard chromatography
  • 製品の状態Liquid
  • 備考Please prevent freeze thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 10% Glycerol

関連情報

  • 別名
    • Chloride channel ABP
    • Chloride intracellular channel 1
    • Chloride intracellular channel protein 1
    • CLIC 1
    • CLIC1
    • CLIC1_HUMAN
    • G6
    • hRNCC
    • NCC 27
    • NCC27
    • Nuclear chloride ion channel 27
    • Nuclear chloride ion channel protein
    • p64CLCP
    • Regulatory nuclear chloride ion channel protein
    • RNCC protein
    see all
  • 機能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
  • 組織特異性Expression is prominent in heart, placenta, liver, kidney and pancreas.
  • 配列類似性Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • ドメインMembers of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • 翻訳後修飾Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
  • 細胞内局在Nucleus. Nucleus membrane. Cytoplasm. Cell membrane. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt

Recombinant Human CLIC1 protein (ab119166) 使用論文

ab119166 has not yet been referenced specifically in any publications.

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