製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P51790
    • 生物種Human
    • 配列MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGD TAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCK
    • 分子量37 kDa including tags
    • 領域1 to 99

特性

Our Abpromise guarantee covers the use of ab114666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein. Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Chloride channel 3
    • Chloride channel protein 3
    • Chloride channel, voltage-sensitive 3
    • Chloride transporter ClC 3
    • Chloride transporter ClC-3
    • Chloride transporter ClC3
    • ClC 3
    • ClC-3
    • ClC3
    • CLCN 3
    • CLCN3
    • CLCN3_HUMAN
    • DKFZp564I0463
    • H(+)/Cl(-) exchange transporter 3
    see all
  • 機能Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
  • 組織特異性Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).
  • 配列類似性Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
    Contains 2 CBS domains.
  • ドメインIsoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC.
  • 翻訳後修飾N-glycosylated.
  • 細胞内局在Membrane. Early endosome membrane. Late endosome membrane. Cytoplasmic vesicle > secretory vesicle membrane. Isoform 1 is localized mainly in early and late endosomes and Membrane. Early endosome membrane. Late endosome membrane. Golgi apparatus membrane. Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi.
  • Information by UniProt

Recombinant Human CLCN3 protein 画像

  • SDS-PAGE analysis of ab114666 on a 12.5% gel stained with Coomassie Blue.

Recombinant Human CLCN3 protein (ab114666) 使用論文

ab114666 has not yet been referenced specifically in any publications.

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