機能Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.
配列類似性Belongs to the CINP family.
翻訳後修飾Phosphorylated by CDC7 but not by CDK2.
細胞内局在Nucleus. Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.