製品の概要

  • 製品名Recombinant Human Chd1 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O14646
    • 生物種Human
    • 配列IKALKDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHK SIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGS
    • 分子量36 kDa including tags
    • 領域1177 to 1272

特性

Our Abpromise guarantee covers the use of ab117050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    Western blot

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • ATP dependent helicase CHD 1
    • ATP-dependent helicase CHD1
    • CHD 1
    • CHD-1
    • Chd1
    • CHD1_HUMAN
    • Chromodomain helicase DNA binding protein 1
    • Chromodomain-helicase-DNA-binding protein 1
    • DKFZp686E2337
    • OTTHUMP00000222625
    see all
  • 機能ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
  • 配列類似性Belongs to the SNF2/RAD54 helicase family.
    Contains 2 chromo domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • ドメインThe 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
  • 細胞内局在Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
  • Information by UniProt

Recombinant Human Chd1 protein 画像

  • 12.5% SDS-PAGE showing ab117050 at approximately 36.19 kDa.
    Stained with Coomassie Blue.

Recombinant Human Chd1 protein (ab117050) 使用論文

ab117050 has not yet been referenced specifically in any publications.

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