Recombinant Human Cellular Apoptosis Susceptibility protein (ab114716)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLL EKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLM LSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVL RTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKVWNASW
    • 分子量
      48 kDa including tags
    • 領域
      1 to 195

特性

Our Abpromise guarantee covers the use of ab114716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CAS
    • Cellular apoptosis susceptibility protein
    • Chromosome segregation 1 (yeast homolog) like
    • Chromosome segregation 1 Like
    • Chromosome segregation 1 like protein
    • Chromosome segregation 1-like protein
    • Chromosome segregation gene CSE1
    • CSE 1
    • CSE 1 chromosome segregation 1 like
    • CSE 1 chromosome segregation 1 like protein
    • CSE 1L
    • CSE1
    • CSE1 chromosome segregation 1 like
    • CSE1 chromosome segregation 1 like (yeast)
    • CSE1 chromosome segregation 1 like protein
    • CSE1L
    • Exp 2
    • Exp2
    • Exportin 2
    • Exportin-2
    • Exportin2
    • Importin alpha re exporter
    • Importin-alpha re-exporter
    • MGC117283
    • MGC130036
    • MGC130037
    • XPO 2
    • XPO2
    • XPO2_HUMAN
    see all
  • 機能
    Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 組織特異性
    Highly expressed in proliferating cells.
  • 配列類似性
    Belongs to the XPO2/CSE1 family.
    Contains 1 importin N-terminal domain.
  • 細胞内局在
    Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114716 at approximately 47.52 kDa stained with Coomassie Blue.

参考文献

ab114716 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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