The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml.
Best use within three months from the date of receipt of this protein.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Cellular apoptosis susceptibility protein
Chromosome segregation 1 (yeast homolog) like
Chromosome segregation 1 Like
Chromosome segregation 1 like protein
Chromosome segregation 1-like protein
Chromosome segregation gene CSE1
CSE 1 chromosome segregation 1 like
CSE 1 chromosome segregation 1 like protein
CSE1 chromosome segregation 1 like
CSE1 chromosome segregation 1 like (yeast)
CSE1 chromosome segregation 1 like protein
Importin alpha re exporter
機能Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
組織特異性Highly expressed in proliferating cells.
配列類似性Belongs to the XPO2/CSE1 family. Contains 1 importin N-terminal domain.
細胞内局在Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.