製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MASMTGGQQM GRGSHMQTIK CVVVGDGAVG KTCLLISYTT NKFPSEYVPT VFDNYAVTVM IGGEPYTLGL FDTAGQEDYD RLRPLSYPQT DVFLVCFSVV SPSSFENVKE KWVPEITHHC PKTPFLLVGT QIDLRDDPST IEKLAKNKQK PITPETAEKL ARDLKAVKYV ECSALTQKGL KNVFDEAILA ALEPPEPKKS RRC

特性

Our Abpromise guarantee covers the use of ab87713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

  • 精製度> 95 % SDS-PAGE.
    ab87713 is purified using conventional chromatography techniques. Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method).
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 2mM EDTA, 1mM DTT, pH 8.0

関連情報

  • 別名
    • CDC42
    • CDC42_HUMAN
    • CDC42Hs
    • Cell division control protein 42 homolog
    • Cell division cycle 42
    • Cell division cycle 42 (GTP binding protein 25kDa)
    • dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
    • dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
    • G25K
    • G25K GTP-binding protein
    • Growth regulating protein
    • GTP binding protein 25kDa
    • Small GTP binding protein CDC42
    • TKS
    see all
  • 機能Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia.
  • 配列類似性Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
  • 翻訳後修飾AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • 細胞内局在Cell membrane.
  • Information by UniProt

Recombinant Human CDC42 protein 画像

  • 15% SDS-PAGE showing ab87713 at approximately 22.4kDa (3µg).

Recombinant Human CDC42 protein (ab87713) 使用論文

ab87713 has not yet been referenced specifically in any publications.

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