製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P40259
    • 生物種Human
    • 配列MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSP RFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQ NESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQ LKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLD IDQTATYEDIVTLRTGEVKWSVGEHPGQE
    • 分子量51 kDa including tags
    • 領域1 to 229

特性

Our Abpromise guarantee covers the use of ab114420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    Western blot

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AGM6
    • B cell antigen receptor complex associated protein beta chain
    • B cell specific glycoprotein B29
    • B-cell antigen receptor complex-associated protein beta chain
    • B-cell-specific glycoprotein B29
    • B29
    • B29/Ig-beta/CD79b
    • CD 79b
    • CD79b
    • CD79b antigen
    • CD79b antigen (immunoglobulin associated beta)
    • CD79b molecule
    • CD79b molecule immunoglobulin associated beta
    • CD79b protein
    • CD79B_HUMAN
    • Ig beta
    • Ig-beta
    • IGB
    • Igbeta
    • Immunoglobulin associated B29
    • Immunoglobulin associated B29 protein
    • Immunoglobulin associated beta
    • Immunoglobulin associated protein
    • Immunoglobulin-associated B29 protein
    • MGC108607
    see all
  • 機能Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • 組織特異性B-cells.
  • 関連疾患Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
  • 配列類似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 翻訳後修飾Phosphorylated on tyrosine upon B-cell activation.
  • 細胞内局在Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt

Recombinant Human CD79b protein 画像

  • ab114420 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human CD79b protein (ab114420) 使用論文

ab114420 has not yet been referenced specifically in any publications.

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