The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Best use within three months from the date of receipt of this protein.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione
CD3 antigen, zeta polypeptide, isoform CRA_b
CD3 antigen, zeta subunit
CD3Z antigen zeta polypeptide (TiT3 complex)
T cell receptor T3 zeta chain
T cell surface glycoprotein CD3 zeta chain
T-cell antigen receptor complex, zeta subunit of CD3
T-cell receptor T3 zeta chain
T-cell surface glycoprotein CD3 zeta chain
TCR zeta chain
機能Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
関連疾患Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
配列類似性Belongs to the CD3Z/FCER1G family. Contains 3 ITAM domains.
ドメインThe ITAM domains mediate interaction with SHB.
翻訳後修飾Phosphorylated on Tyr residues after T-cell receptor triggering.