The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
エンドトキシン・レベル< 0.100 Eu/µg
% SDS-PAGE. Greater than 97% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
glycoprotein 34 kd
OX40 antigen ligand
TAX transcriptionally-activated glycoprotein 1
Tumor necrosis factor (ligand) superfamily member 4
Tumor necrosis factor ligand superfamily member 4
機能Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
関連疾患Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T cell-APC interaction and the functional consequences of T cell activation, thereby destabilizing peripheral tolerance.