製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P15144
    • 生物種Human
    • 分子量21 kDa
    • 領域506 to 688

特性

Our Abpromise guarantee covers the use of ab126023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • Alanyl (membrane) aminopeptidase
    • Alanyl aminopeptidase
    • Aminopeptidase M
    • Aminopeptidase N
    • AMPN_HUMAN
    • ANPEP
    • AP M
    • AP N
    • AP-M
    • AP-N
    • APN
    • CD 13
    • CD13
    • CD13 antigen
    • gp150
    • hAPN
    • LAP 1
    • LAP1
    • Microsomal aminopeptidase
    • Myeloid plasma membrane glycoprotein CD13
    • p150
    • PEPN
    see all
  • 機能Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
  • 組織特異性Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
  • 配列類似性Belongs to the peptidase M1 family.
  • ドメインAmino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies).
  • 翻訳後修飾Sulfated.
    N- and O-glycosylated.
    May undergo proteolysis and give rise to a soluble form.
  • 細胞内局在Cell membrane. Cytoplasm > cytosol. A soluble form has also been detected.
  • Information by UniProt

Recombinant Human CD13 protein (ab126023) 使用論文

ab126023 has not yet been referenced specifically in any publications.

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