製品の概要

  • 製品名
    Recombinant Human CD11b protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      29 kDa
    • 領域
      567 to 825

特性

Our Abpromise guarantee covers the use of ab126010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成
    Reconstitute with water to desired concentration.

関連情報

  • 別名
    • antigen CD11b (p170)
    • Antigen CD11b p170
    • CD11 antigen like family member B
    • CD11 antigen-like family member B
    • CD11b
    • CD11b/CD18
    • CD49d
    • Cell surface glycoprotein MAC-1 subunit alpha
    • Complement component 3 receptor 3 subunit
    • Complement Component Receptor 3 Alpha
    • Complement receptor type 3, alpha subunit
    • CR 3 alpha chain
    • CR 3 alpha chain (CR3A)
    • CR-3 alpha chain
    • CR3
    • CR3A
    • F730045J24Rik
    • Integrin Alpha M
    • Integrin alpha M chain
    • Integrin alpha-M
    • Integrin beta 2 alpha subunit
    • Integrin subunit alpha M
    • integrin, alpha M (complement component 3 receptor 3 subunit)
    • ITAM_HUMAN
    • ITGAM
    • Leukocyte adhesion receptor MO1
    • Ly-40
    • MAC 1
    • Mac-1a
    • MAC1
    • Mac1, alpha subunit
    • MAC1A
    • Macrophage antigen alpha polypeptide
    • MGC117044
    • Mo1, alpha subunit
    • MO1A
    • Neutrophil adherence receptor
    • Neutrophil adherence receptor alpha M subunit
    • SLEB6
    see all
  • 機能
    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
  • 組織特異性
    Predominantly expressed in monocytes and granulocytes.
  • 関連疾患
    Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 配列類似性
    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • ドメイン
    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • 細胞内局在
    Membrane.
  • Information by UniProt

参考文献

ab126010 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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