製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMEEEGKKGKKPGIVSPFKRVFLKGEKSRDK KAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYL NPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDI ILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLD RAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGAS PHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGAS IHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGI ITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISS DIEALGCSMDQDSA
    • 分子量
      51 kDa including tags
    • 領域
      1 to 444
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    Purity is >95%, by SDS-PAGE and silver stain.
  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • 再構成
    ab113197 is soluble in water and most aqueous buffers and should be reconstituted in water or medium containing at least 0.1% Human or BSA to a concentration not lower than 50 µg/ml.

関連情報

  • 別名
    • C7orf22
    • Ccm2
    • CCM2 gene
    • CCM2_HUMAN
    • Cerebral cavernous malformation 2
    • Cerebral cavernous malformations 2 protein
    • Chromosome 7 open reading frame 22
    • Malcavernin
    • MGC4067
    • MGC4607
    • MGC74868
    • OSM
    • Osmosensing scaffold for MEKK3
    • OTTHUMP00000159554
    • OTTHUMP00000214270
    • OTTHUMP00000214271
    • OTTHUMP00000214273
    • PP10187
    see all
  • 機能
    May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
  • 関連疾患
    Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • 配列類似性
    Contains 1 PID domain.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

画像

  • SDS-PAGE of human recombinant CCM2 (ab113197). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with silver stain.

参考文献

ab113197 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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