Epididymis secretory sperm binding protein Li 130P
HEL S 130P
Lysosomal aspartyl peptidase
Lysosomal aspartyl protease
機能Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
組織特異性Expressed in the aorta extrcellular space (at protein level).
関連疾患Ceroid lipofuscinosis, neuronal, 10
配列類似性Belongs to the peptidase A1 family. Contains 1 peptidase A1 domain.
翻訳後修飾N- and O-glycosylated.
細胞内局在Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).