Recombinant human Caspase 4 protein (ab51994)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab51994 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    5000 units/mg.
  • アプリケーション

    Functional Studies

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Lyophilised
  • 備考


    This protein is a heterotetramer consisting of two large and two small subunits. Active Caspase 4 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays.

    5000 units/mg.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 15% Glycerol, PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    Reconstitute to 1 unit per µl in PBS containing 15% glycerol. Aliquot and store immediately at -80°C.

関連情報

  • 別名
    • Apoptotic cysteine protease Mih1/TX
    • CASP-4
    • CASP4
    • CASP4_HUMAN
    • Caspase 4 apoptosis related cysteine peptidase
    • Caspase-4 subunit 2
    • Caspase4
    • ICE(rel)-II
    • ICE(rel)II
    • ICEREL II
    • ICH2
    • Mih1/TX
    • Protease ICH-2
    • Protease TX
    • TX
    see all
  • 機能
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
  • 組織特異性
    Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
  • 配列類似性
    Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
  • 翻訳後修飾
    The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
  • Information by UniProt

参考文献

ab51994 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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