Recombinant human Casein Kinase 1 gamma 2 protein (ab104025)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号 P78368
    • 生物種Human
    • 分子量73 kDa including tags
    • 領域1 to 415

特性

Our Abpromise guarantee covers the use of ab104025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab104025 was determined to be 30 nmol/min/mg.
  • アプリケーション

    Functional Studies

    Western blot

  • 精製度> 80 % SDS-PAGE.
    Purity was determined to be >85% by densitometry.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Casein kinase 1, gamma 2
    • Casein kinase I isoform gamma 2
    • Casein kinase I isoform gamma-2
    • CK1g2
    • CKI gamma 2
    • CKI-gamma 2
    • CSNK1G 2
    • Csnk1g2
    • KC1G2_HUMAN
    see all
  • 機能Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.
  • 組織特異性Testis.
  • 配列類似性Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant human Casein Kinase 1 gamma 2 protein 画像

  • The Specific activity of ab104025 was determined to be 30 nmol/min/mg.
  • SDS-PAGE showing ab104025 at approximately 73kDa.

Recombinant human Casein Kinase 1 gamma 2 protein (ab104025) 使用論文

ab104025 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry. The only Casein Kinase 1 gamma 2 protein that we carry in the catalogue is ab104025, the protein you found. The concentration of this protein is 0.1 mg/ml. If you need to make a bulk order purchase (of 5 or more uni...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"