Recombinant human Casein Kinase 1 alpha protein (ab102102)

製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      62 kDa including tags
    • 領域
      1 to 337

特性

Our Abpromise guarantee covers the use of ab102102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Specific activity is 120 nmol/min/mg
  • アプリケーション

    Western blot

    Functional Studies

  • 精製度
    > 80 % Densitometry.
    The purity of Casein Kinase 1 alpha protein (Active) was >80% as assessed by densitometry.
  • 製品の状態
    Liquid
  • 備考

    ab91090 (Cow Casein full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Casein kinase 1 alpha 1
    • Casein kinase I isoform alpha
    • CK1
    • CK1A
    • CKI alpha
    • CKI-alpha
    • CKIa
    • Clock regulator kinase
    • Csnk1a1
    • Down regulated in lung cancer
    • HLCDGP1
    • KC1A_HUMAN
    • PRO2975
    see all
  • 機能
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.
  • 配列類似性
    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在
    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Nucleus speckle. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.
  • Information by UniProt

画像

  • ab102102 was determined to be >80% pure by densitometry. MWt 62 kDa.
  • The specific activity of ab102102 was determined to be 120 nmol/min/mg.

参考文献

ab102102 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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