Recombinant Human Cardiac Troponin C protein (ab70106)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 分子量18 kDa

特性

Our Abpromise guarantee covers the use of ab70106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab70106 was purified by proprietary chromatographic techniques. Purity is greater than 95.0% as determined by analysis by RP-HPLC, Anion-exchange FPLC and by reducing and non-reducing SDS-PAGE Silver Stained gel.
  • 製品の状態Liquid
  • 備考For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C.

    Preservative: 0.05% Sodium Azide
    Constituents: 150mM Sodium chloride, 10mM Sodium phosphate, pH 7.0

関連情報

  • 別名
    • tnnc1a
    • Cardiac troponin C
    • slow skeletal and cardiac muscles
    • TN-C
    • TNC
    • Tnnc1
    • TNNC1_HUMAN
    • TNNI3
    • Troponin C
    • Troponin C slow
    • Troponin C1 slow
    see all
  • 機能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • 関連疾患Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt

Recombinant Human Cardiac Troponin C protein (ab70106) 使用論文

ab70106 has not yet been referenced specifically in any publications.

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