製品の概要

  • 製品名Recombinant Human CARD4 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9Y239
    • 生物種Human
    • 分子量25 kDa
    • 領域710 to 936

特性

Our Abpromise guarantee covers the use of ab126000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • CARD 4
    • CARD4
    • Caspase recruitment domain 4
    • Caspase recruitment domain containing protein 4
    • Caspase recruitment domain family member 4
    • Caspase recruitment domain protein 4
    • Caspase recruitment domain-containing protein 4
    • CLR 7.1
    • CLR7.1
    • NLR family CARD domain containing 1
    • NLRC 1
    • NLRC1
    • NOD 1
    • Nod1
    • NOD1 protein
    • NOD1_HUMAN
    • Nucleotide binding oligomerization domain containing 1
    • Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1
    • Nucleotide-binding oligomerization domain-containing protein 1
    • Protein Nod1
    see all
  • 機能Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
  • 組織特異性Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
  • 配列類似性Contains 1 CARD domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 翻訳後修飾Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.
  • 細胞内局在Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
  • Information by UniProt

Recombinant Human CARD4 protein (ab126000) 使用論文

ab126000 has not yet been referenced specifically in any publications.

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