Recombinant Human Calreticulin protein (ab91577)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab91577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: Glycerol, Sodium chloride, Tris buffered saline, 5mM Calcium chloride

関連情報

  • 別名
    • Autoantigen RO
    • CALR
    • CALR protein
    • CALR_HUMAN
    • Calregulin
    • Calreticulin
    • cC1qR
    • CRP55
    • CRT
    • CRTC
    • Endoplasmic reticulum resident protein 60
    • Epididymis secretory sperm binding protein Li 99n
    • ERp60
    • FLJ26680
    • grp60
    • HACBP
    • HEL S 99n
    • RO
    • Sicca syndrome antigen A
    • SSA
    see all
  • 機能Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.
  • 配列類似性Belongs to the calreticulin family.
  • ドメインCan be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
    The interaction with glycans occurs through a binding site in the globular lectin domain.
    The zinc binding sites are localized to the N-domain.
    Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
  • 細胞内局在Endoplasmic reticulum lumen. Cytoplasm > cytosol. Secreted > extracellular space > extracellular matrix. Cell surface. Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.
  • Information by UniProt

Recombinant Human Calreticulin protein 画像

  • SDS-PAGE Analysis of ab91577 stained with Coomassie Blue.
    Lane 1: MW Marker
    Lane 2: 0.5 µg purified Calreticulin
    Lane 3: 1 µg purified Calreticulin
    Lane 4: 2 µg purified Calreticulin
    Lane 5: 5 µg purified Calreticulin
  • All lanes : Recombinant Human Calreticulin protein (ab91577) at 1/1000 dilution

    Lane 1 : MW Marker
    Lane 2 : 50ng Calreticulin
    Lane 3 : 100ng Calreticulin

Recombinant Human Calreticulin protein (ab91577) 使用論文

ab91577 has not yet been referenced specifically in any publications.

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Yes, this is the full length protein. For full length proteins we have left the start and stop amino acids as 0, since there is not a start and stop like there is for a peptide.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"