Recombinant Human Calreticulin protein (ab91577)

関連情報

• 別名
  • Autoantigen RO
  • CALR
  • CALR protein

  • CALR_HUMAN
  • Calregulin
  • Calreticulin
  • cC1qR
  • CRP55
  • CRT
  • CRTC
  • Endoplasmic reticulum resident protein 60
  • Epididymis secretory sperm binding protein Li 99n
  • ERp60
  • FLJ26680
  • grp60
  • HACBP
  • HEL S 99n
  • RO
  • Sicca syndrome antigen A
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • SSA

  see all
• 機能Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.
• 配列類似性Belongs to the calreticulin family.
• ドメインCan be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
  The interaction with glycans occurs through a binding site in the globular lectin domain.
  The zinc binding sites are localized to the N-domain.
  Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
• 細胞内局在Endoplasmic reticulum lumen. Cytoplasm > cytosol. Secreted > extracellular space > extracellular matrix. Cell surface. Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.

• Target information above from: UniProt accession P27797 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt