Recombinant Human CACNB2 protein (ab114486)

製品の概要

  • 製品名
    Recombinant Human CACNB2 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      PSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKR MPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQ
    • 分子量
      35 kDa including tags
    • 領域
      213 to 301

特性

Our Abpromise guarantee covers the use of ab114486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 ug/ul.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AW060387
    • Ca(V) beta 2
    • CAB2
    • CACB2_HUMAN
    • CACNB2
    • CACNLB2
    • Calcium channel voltage dependent subunit beta 2
    • Calcium channel voltage-dependent subunit beta 2
    • Calcium channel, voltage dependent, beta 2 subunit
    • CAVB2
    • Cavbeta2
    • Cchb2
    • FLJ23743
    • Lambert Eaton Myasthenic syndrome antigen
    • Lambert Eaton myasthenic syndrome antigen B
    • Lambert-Eaton myasthenic syndrome antigen B
    • MGC129334
    • MGC129335
    • Myasthenic (Lambert Eaton) syndrome antigen B
    • Myasthenic syndrome antigen B
    • MYSB
    • Voltage dependent L type calcium channel subunit beta 2
    • Voltage-dependent L-type calcium channel subunit beta-2
    see all
  • 機能
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 組織特異性
    Expressed in all tissues.
  • 関連疾患
    Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4) [MIM:611876]. BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • 配列類似性
    Belongs to the calcium channel beta subunit family.
    Contains 1 SH3 domain.
  • 細胞内局在
    Cell membrane > sarcolemma.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114486 at approximately 35.42kDa stained with Coomassie Blue.

参考文献

ab114486 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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