Recombinant Human Brachyury / Bry protein (ab114235)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESE LWLRFKELTNEMIVTKNGRRMFPVL KVNVSGLDPNAMYSFLLDFVAAD NHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKL TN KLNGGGQIMLNSLHKYEPRIHIVRVGDPQRMITSHCFPETQFIAVT AYQNEEITALKIKYNPFAKAFLDAKERSD HKEMMEEPGDSQQPGYSQS YSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWS VSNGAV TPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPL YEGAAAATDIVDSQYDAAAQGRLIASWTPVSPP SM
    • 分子量
      68 kDa including tags
    • 領域
      1 to 377

関連製品

特性

Our Abpromise guarantee covers the use of ab114235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • BRAC_HUMAN
    • Brachyury homolog
    • Brachyury protein
    • Bry
    • MGC104817
    • Protein T
    • SAVA
    • T
    • T brachyury homolog
    • T brachyury transcription factor
    • T Protein
    • T, brachyury homolog (mouse)
    • TFT
    • Transcription factor T
    see all
  • 機能
    Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
  • 関連疾患
    Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.
    T is involved in susceptibility to the development of chordoma (CHDM) [MIM:215400]. Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Note=Susceptibility to development of chordomas is due to a T gene duplication.
  • 配列類似性
    Contains 1 T-box DNA-binding domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114235 at approximately 67.54kDa stained with Coomassie Blue.

参考文献

ab114235 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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