Recombinant Human Brachyury / Bry protein (ab114235)
Key features and details
- Expression system: Wheat germ
- Suitable for: ELISA, SDS-PAGE, WB
製品の詳細
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製品名
Recombinant Human Brachyury / Bry protein -
発現系
Wheat germ -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESE LWLRFKELTNEMIVTKNGRRMFPVL KVNVSGLDPNAMYSFLLDFVAAD NHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKL TN KLNGGGQIMLNSLHKYEPRIHIVRVGDPQRMITSHCFPETQFIAVT AYQNEEITALKIKYNPFAKAFLDAKERSD HKEMMEEPGDSQQPGYSQS YSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWS VSNGAV TPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPL YEGAAAATDIVDSQYDAAAQGRLIASWTPVSPP SM -
予測される分子量
68 kDa including tags -
領域
1 to 377
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab114235 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
ELISA
SDS-PAGE
Western blot
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製品の状態
Liquid -
備考
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.3% Glutathione, 0.79% Tris HCl
関連情報
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別名
- BRAC_HUMAN
- Brachyury homolog
- Brachyury protein
see all -
機能
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. -
関連疾患
Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.
T is involved in susceptibility to the development of chordoma (CHDM) [MIM:215400]. Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Note=Susceptibility to development of chordomas is due to a T gene duplication. -
配列類似性
Contains 1 T-box DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab114235 は論文での使用が確認できていません。