Recombinant Human BORIS protein (ab112433)

製品の概要

  • 製品名Recombinant Human BORIS protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q8NI51
    • 生物種Human
    • 配列AERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQPTAGQADAEKAK STKNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLK T
    • 分子量37 kDa including tags
    • 領域193 to 293
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • BORIS like protein
    • Brother of the regulator of imprinted sites
    • Cancer/testis antigen 27
    • CCCTC binding factor (zinc finger protein) like
    • CCCTC-binding factor
    • CT27
    • CTCF paralog
    • CTCF T
    • CTCF-like protein
    • Ctcfl
    • CTCFL_HUMAN
    • dJ579F20.2
    • HMG 1L1
    • HMGB1L1
    • MGC163358
    • MGC169105
    • MGC169106
    • Putative high mobility group protein 1 like 1
    • Putative high mobility group protein B1 like 1
    • Transcriptional repressor CTCFL
    • Zinc finger protein CTCF-T
    see all
  • 機能Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
  • 組織特異性Testis specific. Specifically expressed in primary spermatocytes.
  • 配列類似性Belongs to the CTCF zinc-finger protein family.
    Contains 11 C2H2-type zinc fingers.
  • 発生段階Is up-regulated in primary spermatocytes (expression overlapping with the genome-wide erasure of methylation) to become silenced on activation of CTCF in post-meiotic germline cells (expression corresponding to DNA remethylation).
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human BORIS protein 画像

  • ab112433 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human BORIS protein (ab112433) 使用論文

ab112433 has not yet been referenced specifically in any publications.

Product Wall


ab112433 has an N-terminal GST tag.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"