製品の概要

  • 製品名
    Recombinant Human Borealin/CDCA8 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMRKLASFLKDFDREVEIRIKQIESDRQNLL KEVDNLYNIEILRLPKALREMNWLDYFALGGNKQALEEAATADLDITEIN KLTAEAIQTPLKSAKTRKVIQVDEMIVEEEEEEENERKNLQTARVKRCPP SKKRTQSIQGKGKGKRSSRANTVTPAVGRLEVSMVKPTPGLTPRFDSRVF KTPGLRTPAAGERIYNISGNGSPLADSKEIFLTVPVGGGESLRLLASDLQ RHSIAQLDPEALGNIKKLSNRLAQICSSIRTHK
    • 分子量
      32 kDa including tags
    • 領域
      19 to 280
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab107144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 質量分析
    MALDI-TOF
  • 精製度
    > 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0

関連情報

  • 別名
    • BOR
    • BOREA_HUMAN
    • Borealin
    • CDCA8
    • Cell division cycle associated 8
    • cell division cycle associated protein 8
    • Cell division cycle-associated protein 8
    • Dasra B
    • Dasra-B
    • DasraB
    • FLJ10468
    • FLJ12042
    • hDasra B
    • hDasra-B
    • MESRGP
    • OTTHUMP00000004514
    • pluripotent embryonic stem cell related gene 3 protein
    • Pluripotent embryonic stem cell-related gene 3 protein
    see all
  • 機能
    Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
  • 配列類似性
    Belongs to the borealin family.
  • 発生段階
    Cell-cycle regulated. Increases during G2/M phase and then reduces after exit from M phase.
  • ドメイン
    The C-terminal region (aa 207-280) represents the dimerization motif.
  • 翻訳後修飾
    Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230.
    Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.
  • 細胞内局在
    Nucleus > nucleolus. Cytoplasm. Cytoplasm > cytoskeleton > spindle. Chromosome > centromere. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.
  • Information by UniProt

Recombinant Human Borealin/CDCA8 protein 画像

  • ab107144 at 3 µg analysed by 15% SDS PAGE.

Recombinant Human Borealin/CDCA8 protein (ab107144) 使用論文

This product has been referenced in:

See 1 Publication for this product

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