製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      29 kDa
    • 領域
      295 to 552

特性

Our Abpromise guarantee covers the use of ab126025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成
    Reconstitute with water to desired concentration.

関連情報

  • 別名
    • BMP type II receptor
    • BMP type-2 receptor
    • BMPR 2
    • BMPR 3
    • BMPR II
    • BMPR-2
    • BMPR-II
    • Bmpr2
    • BMPR2_HUMAN
    • BMPR3
    • BMPRII
    • BMR 2
    • BMR2
    • Bone morphogenetic protein receptor type 2
    • Bone morphogenetic protein receptor type II
    • Bone morphogenetic protein receptor type-2
    • Bone morphogenic protein receptor type II serine threonine kinase
    • BRK 3
    • BRK3
    • PPH 1
    • PPH1
    • Serine threonine kinase type II activin receptor like kinase
    • T ALK
    • TALK
    • Type II activin receptor like kinase
    see all
  • 機能
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
  • 組織特異性
    Highly expressed in heart and liver.
  • 関連疾患
    Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
    Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.
  • 配列類似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在
    Membrane.
  • Information by UniProt

Recombinant Human BMPR2 protein (ab126025) 使用論文

ab126025 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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