Recombinant human BMPR1A protein (ab105907)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P36894
    • 生物種Human
    • 分子量66 kDa including tags
    • 領域187 to 532

関連製品

特性

Our Abpromise guarantee covers the use of ab105907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab105907 was determined to be 1.2 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

  • 精製度> 90 % Densitometry.
    Purity was determined to be >90% by densitometry.
  • 製品の状態Liquid
  • 備考

    ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 10q23del
    • Activin A receptor type II like kinase 3
    • Activin receptor like kinase 3
    • Activin receptor-like kinase 3
    • ACVRLK 3
    • ACVRLK3
    • ALK 3
    • ALK-3
    • ALK3
    • BMP type-1A receptor
    • Bmpr
    • BMPR 1A
    • BMPR-1A
    • Bmpr1a
    • BMR1A_HUMAN
    • Bone morphogenetic protein receptor type IA
    • Bone morphogenetic protein receptor type IA precursor
    • Bone morphogenetic protein receptor type-1A
    • BR 1a
    • BR1a
    • CD 292
    • CD292
    • CD292 antigen
    • EC 2.7.11.30
    • Serine threonine protein kinase receptor R5
    • Serine threonine protein kinase receptor R5 precursor
    • Serine/threonine-protein kinase receptor R5
    • SKR 5
    • SKR5
    • zBMPR IA
    • zBMPRIA
    see all
  • 機能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
  • 組織特異性Highly expressed in skeletal muscle.
  • 関連疾患Juvenile polyposis syndrome
    Polyposis syndrome, mixed hereditary 2
    A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant human BMPR1A protein 画像

  • Kinase Assay demonstrating specific activity of ab105907 at 1.2 nmol/min/mg.
  • SDS-PAGE showing ab105907 at approximately 66kDa.

Recombinant human BMPR1A protein (ab105907) 使用論文

ab105907 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105907.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"