The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
B lymphoma Mo MLV insertion region (mouse)
B lymphoma Mo MLV insertion region 1 homolog
BMI1 polycomb ring finger oncogene
Flvi 2/bmi 1
Murine leukemia viral (bmi 1) oncogene homolog
Oncogene BMI 1
Polycomb complex protein BMI 1
Polycomb complex protein BMI-1
Polycomb group protein Bmi1
Polycomb group ring finger 4
Polycomb group RING finger protein 4
RING finger protein 51
機能Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
配列類似性Contains 1 RING-type zinc finger.
翻訳後修飾Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.