製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected BTI-TN-5B1-4 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMGLVSSKKPDKEKPIKEKDKGQWSPLKVSA QDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQML KGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQG RKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEA FLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGS RLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFG LARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVT YGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER PTFEFLQSVLEDFYTATERQYELQP
    • 分子量
      60 kDa including tags
    • 領域
      1 to 505
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 80 % SDS-PAGE.
    ab113606 was purified using conventional chromatography techniques. It is at least 80% pure by SDS PAGE.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.002% PMSF, 0.077% DTT, 0.32% Tris HCl, 50% Glycerol, 1.46% Sodium chloride, 0.003% EDTA

関連情報

  • 別名
    • B lymphocyte kinase
    • B lymphoid tyrosine kinase
    • Blk
    • BLK nonreceptor tyrosine kinase
    • BLK_HUMAN
    • EC 2.7.10.2
    • MGC 10442
    • MGC10442
    • MODY 11
    • MODY11
    • P55 BLK
    • p55-BLK
    • Tyrosine kinase B lymphocyte specific
    • Tyrosine protein kinase
    • Tyrosine-protein kinase BLK
    see all
  • 機能
    Modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
  • 組織特異性
    Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
  • 関連疾患
    Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) [MIM:613375]. MODY11 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 配列類似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Information by UniProt

画像

  • 15% SDS-PAGE showing ab113606 (3 µg) at approximately 59.8 kDa.

参考文献

ab113606 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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