製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q16143
    • 生物種Human
    • 配列MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
    • 領域1 to 134

特性

Our Abpromise guarantee covers the use of ab48853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 20mM Tris HCl, 1mM Magnesium chloride, pH 7.5

関連情報

  • 別名
    • 14 kDa brain-specific protein
    • Beta-synuclein
    • Phosphoneuroprotein 14
    • PNP14
    • Sncb
    • Synuclein beta
    • SYUB_HUMAN
    see all
  • 機能Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
  • 組織特異性Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
  • 配列類似性Belongs to the synuclein family.
  • 翻訳後修飾Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human beta Synuclein protein 画像

  • ab48853 in 15%SDS-PAGE

Recombinant Human beta Synuclein protein (ab48853) 使用論文

This product has been referenced in:
  • Surgucheva I  et al. ?-Synuclein: seeding of a-synuclein aggregation and transmission between cells. Biochemistry 51:4743-54 (2012). Read more (PubMed: 22620680) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab48853.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"