The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.3% Glutathione
Beta crystallin A3
Beta crystallin A3 isoform A1 Delta4 form
Beta crystallin A3 isoform A1 Delta7 form
Beta crystallin A3 isoform A1 Delta8 form
Crystallin beta A1
Crystallin beta A3
Eye lens structural protein
機能Crystallins are the dominant structural components of the vertebrate eye lens.
関連疾患Defects in CRYBA1 are the cause of cataract congenital zonular with sutural opacities (CCZS) [MIM:600881]. A form of zonular cataract. Zonular or lamellar cataracts are concentric opacities, broad or narrow, usually consisting of powdery white dots affecting one lamella or zonule of an otherwise clear lens.
配列類似性Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains.
ドメインHas a two-domain beta-structure, folded into four very similar Greek key motifs.
翻訳後修飾Specific cleavages in the N-terminal arm occur during lens maturation and give rise to several truncated forms. Cleavages do not seem to have adverse effects on solubility. S-methylation and glutathionylation occur in normal young lenses and do not seem to be detrimental. Isoform A1 initiator methionine is removed. The new N-terminal amino acid is then N-acetylated.