Recombinant Human beta 2 Microglobulin protein (ab98116)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, MS
製品の詳細
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製品名
Recombinant Human beta 2 Microglobulin protein
beta 2 Microglobulin タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE.
ab98116 is purified by using conventional chromatography techniques. -
発現系
Escherichia coli -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MGSSHHHHHH SSGLVPRGSH MIQRTPKIQV YSRHPAENGK SNFLNCYVSG FHPSDIEVDL LKNGERIEKV EHSDLSFSKD WSFYLLYYTE FTPTEKDEYA CRVNHVTLSQ PKIVKWDRDM -
予測される分子量
14 kDa including tags -
領域
21 to 119 -
タグ
His tag N-Terminus
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関連製品
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Related Products
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Biotin Anti-beta 2 Microglobulin antibody [B2M-01] (ab21899)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)
- Anti-beta 2 Microglobulin antibody (ab6608)
- Anti-beta 2 Microglobulin antibody [EP2978Y] (ab75853)
- Anti-beta 2 Microglobulin antibody [B2M-01] (ab759)
特性
Our Abpromise guarantee covers the use of ab98116 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Mass Spectrometry
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質量分析
MALDI-TOF -
製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00
Constituents: 0.0308% DTT, 0.316% Tris HCl, 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride
関連情報
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別名
- B2M
- B2MG_HUMAN
- Beta 2 microglobin
see all -
機能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. -
関連疾患
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. -
配列類似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
翻訳後修飾
Glycation of Ile-21 is observed in long-term hemodialysis patients. -
細胞内局在
Secreted. Detected in serum and urine. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab98116 は 3 報の論文で使用されています。
- Feng Y et al. METTL3/METTL14 Transactivation and m6A-Dependent TGF-ß1 Translation in Activated Kupffer Cells. Cell Mol Gastroenterol Hepatol 12:839-856 (2021). PubMed: 33992834
- Feng Y et al. GR-mediated transcriptional regulation of m6A metabolic genes contributes to diet-induced fatty liver in hens. J Anim Sci Biotechnol 12:117 (2021). PubMed: 34872591
- Feng Y et al. Chronic corticosterone exposure induces liver inflammation and fibrosis in association with m6A-linked post-transcriptional suppression of heat shock proteins in chicken. Cell Stress Chaperones 25:47-56 (2020). PubMed: 31745845