Recombinant Human Bcl2L2 protein (ab117689)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q92843
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT
    • 分子量21 kDa including tags
    • 領域1 to 172
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab117689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab117689 is purified by proprietary chromatographic techniques.
  • 製品の状態Liquid
  • 備考For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 10% Glycerol

関連情報

  • 別名
    • Apoptosis regulator BCL W
    • Apoptosis regulator Bcl-W
    • B2CL2_HUMAN
    • BCL 2 Like 2
    • Bcl 2 like 2 protein
    • Bcl 2L2
    • BCL W
    • Bcl-2-like protein 2
    • Bcl2 L2
    • BCL2 like 2
    • BCL2 like 2 protein
    • Bcl2-L-2
    • Bcl2l2
    • BCLW
    • KIAA0271
    • PPP1R51
    • Protein phosphatase 1 regulatory subunit 51
    see all
  • 機能Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
  • 組織特異性Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
  • 配列類似性Belongs to the Bcl-2 family.
  • ドメインThe BH4 motif seems to be involved in the anti-apoptotic function.
    The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
  • 細胞内局在Mitochondrion membrane. Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
  • Information by UniProt

Recombinant Human Bcl2L2 protein (ab117689) 使用論文

ab117689 has not yet been referenced specifically in any publications.

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