The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.03% Glutathione, 0.79% Tris HCl
Anion exchange protein 1
Anion exchanger 1
Band 3 anion transport protein
Diego blood group
Erythrocyte membrane protein band 3
Erythroid anion exchange protein
Froese blood group
Solute carrier family 4 anion exchanger member 1
Solute carrier family 4 member 1
Swann blood group
Waldner blood group
Wright blood group
機能Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
組織特異性Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871).
関連疾患Ovalocytosis, Southeast Asian Spherocytosis 4 Renal tubular acidosis, distal, autosomal dominant Renal tubular acidosis, distal, with hemolytic anemia Renal tubular acidosis, distal, with normal red cell morphology Cryohydrocytosis
配列類似性Belongs to the anion exchanger (TC 2.A.31) family.
翻訳後修飾Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation. Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation. N-glycosylated.
細胞内局在Cell membrane. Basolateral cell membrane. Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.