Recombinant Human Band 3 protein (ab114402)

製品の概要

  • 製品名Recombinant Human Band 3 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P02730
    • 生物種Human
    • 配列PIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHS LEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYK
    • 分子量37 kDa including tags
    • 領域261 to 360

特性

Our Abpromise guarantee covers the use of ab114402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.03% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AE 1
    • AE1
    • Anion exchange protein 1
    • Anion exchanger 1
    • B3AT_HUMAN
    • Band 3 anion transport protein
    • BND3
    • CD233
    • DI
    • Diego blood group
    • EMPB3
    • EPB3
    • Erythrocyte membrane protein band 3
    • Erythroid anion exchange protein
    • FR
    • Froese blood group
    • RTA1A
    • SLC4A1
    • Solute carrier family 4 anion exchanger member 1
    • Solute carrier family 4 member 1
    • SW
    • Swann blood group
    • Waldner blood group
    • WD
    • WD1
    • WR
    • Wright blood group
    see all
  • 機能Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
  • 組織特異性Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871).
  • 関連疾患Ovalocytosis, Southeast Asian
    Spherocytosis 4
    Renal tubular acidosis, distal, autosomal dominant
    Renal tubular acidosis, distal, with hemolytic anemia
    Renal tubular acidosis, distal, with normal red cell morphology
    Cryohydrocytosis
  • 配列類似性Belongs to the anion exchanger (TC 2.A.31) family.
  • 翻訳後修飾Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation.
    Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation.
    N-glycosylated.
  • 細胞内局在Cell membrane. Basolateral cell membrane. Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney.
  • Information by UniProt

Recombinant Human Band 3 protein 画像

  • 12.5% SDS-PAGE analysis of ab114402, stained with Coomassie Blue.

Recombinant Human Band 3 protein (ab114402) 使用論文

ab114402 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"