Recombinant Human BAIAP2 protein (ab119452)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9UQB8
    • 生物種Human
    • 配列MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERA VQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVP PELAPFVGRM SAQESTPIMN GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPK NSYATTAENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLL DKDDLAIPPP DYGAASRAFP AQTASGFKQR PYSVAVPAFS QGLDDYGARS MSSGSGTLVS TVVEHHHHHH
    • 分子量58 kDa including tags
    • 領域1 to 522
    • タグHis tag C-Terminus

特性

Our Abpromise guarantee covers the use of ab119452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab119452 was purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 30% Glycerol, 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride

関連情報

  • 別名
    • BAI-associated protein 2
    • BAI1 associated protein 2
    • BAI1-associated protein 2
    • BAIAP 2
    • Baiap2
    • BAIP2_HUMAN
    • BAP2
    • Brain-specific angiogenesis inhibitor 1-associated protein 2
    • Fas ligand-associated factor 3
    • FLAF3
    • Insulin receptor substrate p53
    • Insulin receptor substrate p53/p58
    • Insulin receptor substrate protein of 53 kDa
    • IRS-58
    • IRSp53
    • IRSp53/58
    • Protein BAP2
    see all
  • 機能Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.
  • 組織特異性Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
  • 配列類似性Contains 1 IMD (IRSp53/MIM homology) domain.
    Contains 1 SH3 domain.
  • ドメインThe IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.
    The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.
  • 翻訳後修飾Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
  • 細胞内局在Cytoplasm. Membrane. Cell projection > filopodium. Cell projection > ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles.
  • Information by UniProt

Recombinant Human BAIAP2 protein 画像

  • 15% SDS-PAGE showing ab119452 at approximately 58.4kDa (3µg).

Recombinant Human BAIAP2 protein (ab119452) 使用論文

ab119452 has not yet been referenced specifically in any publications.

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