製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 領域72 to 345

特性

Our Abpromise guarantee covers the use of ab85158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM MOPS, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

関連情報

  • 別名
    • Bag 1
    • BAG family molecular chaperone regulator 1
    • BAG-1
    • BAG1
    • BAG1_HUMAN
    • BCL 2 associated athanogene
    • BCL 2 Associated Athanogene 1
    • BCL 2 binding athanogene 1
    • Bcl-2-associated athanogene 1
    • BCL2 associated athanogene
    • BCL2 associated athanogene 1
    • Glucocorticoid receptor-associated protein RAP46
    • HAP1
    • Haptoglobin
    • RAP 46
    • RAP46
    see all
  • 機能Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
  • 組織特異性Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
  • 配列類似性Contains 1 BAG domain.
    Contains 1 ubiquitin-like domain.
  • 翻訳後修飾Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 細胞内局在Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus and Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
  • Information by UniProt

Recombinant Human Bag1 protein 画像

  • SDS-PAGE showing ab85158 at approximately 66kDa.

Recombinant Human Bag1 protein (ab85158) 使用論文

ab85158 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"