製品の概要
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製品名Recombinant human BAFF Receptor protein
BAFF Receptor タンパク質・ペプチド 製品一覧 -
タンパク質長Protein fragment
製品の詳細
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由来Recombinant
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由来Escherichia coli
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アミノ酸配列
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生物種Human
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特性
Our Abpromise guarantee covers the use of ab55757 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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生理活性Block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 µg/ml in the presence of 1.0 µg/ml of human soluble BAFF.
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アプリケーション
SDS-PAGE
Functional Studies
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精製度> 95 % SDS-PAGE.
Purity: > 95% by SDS-PAGE and HPLC analyses. Endotoxin level < 0.1 ng per µg of BAFF-R -
製品の状態Lyophilised
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: None
Endotoxin level: < 0.1 ng per µg of soluble BAFF.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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再構成Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers.
関連情報
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別名
- B cell activating factor receptor
- B-cell-activating factor receptor
- BAFF R
see all -
機能B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
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組織特異性Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
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関連疾患Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
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配列類似性Contains 1 TNFR-Cys repeat.
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細胞内局在Membrane.
- Information by UniProt
参考文献
ab55757 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"