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別名
- ARK-2
- ARK2
- AurB
- AURKB
- AURKB_HUMAN
- Aurora 1
- Aurora and Ipl1 like midbody associated protein 1
- Aurora kinase B
- Aurora related kinase 2
- Aurora- and Ipl1-like midbody-associated protein 1
- Aurora-B
- Aurora-related kinase 2
- Aurora/IPL1 related kinase 2
- Aurora/IPL1-related kinase 2
- IPL1
- PPP1R48
- Protein phosphatase 1 regulatory subunit 48
- Serine/theronine kinase 12
- Serine/threonine protein kinase 12
- Serine/threonine-protein kinase 12
- Serine/threonine-protein kinase aurora-B
- STK-1
- STK1
- STK12
- STK5
see all
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機能
May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.
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組織特異性
High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
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関連疾患
Note=Disruptive regulation of expression is a possibile mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.
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配列類似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Contains 1 protein kinase domain.
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翻訳後修飾
Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
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細胞内局在
Nucleus. Chromosome. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body.
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Information by UniProt