Recombinant Human ATP-binding cassette sub-family A member 3 protein (ab125999)

製品の概要

  • 製品名Recombinant Human ATP-binding cassette sub-family A member 3 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q99758
    • 生物種Human
    • 分子量20 kDa
    • 領域38 to 209

特性

Our Abpromise guarantee covers the use of ab125999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • ABC 3
    • ABC C
    • ABC C transporter
    • ABC transporter 3
    • ABC-C transporter
    • ABC3
    • ABCA 3
    • Abca3
    • ABCA3 protein
    • ABCA3_HUMAN
    • ABCC
    • ATP binding cassette 3
    • ATP binding cassette sub family A (ABC1) member 3
    • ATP binding cassette sub family A member 3
    • ATP binding cassette transporter 3
    • ATP-binding cassette 3
    • ATP-binding cassette sub-family A member 3
    • ATP-binding cassette transporter 3
    • CED7. C. elegans, homolog of
    • EST111653
    • LBM 180
    • LBM180
    • MGC72201
    • P180 Lamellar Body Protein
    • SMDP3
    see all
  • 機能Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
  • 組織特異性Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma.
  • 関連疾患Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • 配列類似性Belongs to the ABC transporter superfamily. ABCA family.
    Contains 2 ABC transporter domains.
  • ドメインMultifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant Human ATP-binding cassette sub-family A member 3 protein (ab125999) 使用論文

ab125999 has not yet been referenced specifically in any publications.

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