ATG4 autophagy related 4 homolog B (S. cerevisiae)
AUT like 1 cysteine endopeptidase
AUT-like 1 cysteine endopeptidase
Autophagy related cysteine endopeptidase 1
Autophagy related protein 4 homolog B
Autophagy-related cysteine endopeptidase 1
Autophagy-related protein 4 homolog B
Cysteine protease ATG4B
機能Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
組織特異性Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.