ASPH is thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor like domains of various proteins.
Endoplasmic reticulum; endoplasmic reticulum membrane; Single-pass type II membrane protein.
SDS-PAGE - Aspartate beta hydroxylase protein (His tag) (ab93737)
15% SDS-PAGE analysis of ab93737 (3µg)
has not yet been referenced specifically in any publications.