Recombinant Human ASIC3 protein (ab126012)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Human ASIC3 protein -
精製度
> 90 % SDS-PAGE.
Purified via His tag -
発現系
Escherichia coli -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
予測される分子量
25 kDa -
領域
83 to 301
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab126012 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Lyophilized -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at -20°C.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
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再構成Reconstitute with water to desired concentration.
関連情報
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別名
- ACCN 3
- Accn3
- ACCN3_HUMAN
see all -
機能
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. -
組織特異性
Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. -
配列類似性
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN3 subfamily. -
発生段階
Expressed in fetal tissues, expression increases in lung and kidney adult tissues. -
ドメイン
The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1. -
翻訳後修飾
Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ACCN3/ASIC3-ACCN1/ASIC2b channel, but does not activate a homomeric ACCN3 channel. -
細胞内局在
Cell membrane. Cytoplasm. Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab126012 は論文での使用が確認できていません。