Recombinant Human AP2 alpha protein (ab114726)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P05549
    • 生物種Human
    • 配列SGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPH AIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGV VNPNEVF
    • 分子量37 kDa including tags
    • 領域99 to 205

関連製品

特性

Our Abpromise guarantee covers the use of ab114726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • Activating enhancer binding protein 2 alpha
    • Activating enhancer-binding protein 2-alpha
    • Activator protein 2
    • AP 2 transcription factor
    • AP 2alpha
    • AP-2
    • AP-2 transcription factor
    • AP2
    • AP2 Transcription Factor
    • AP2-alpha
    • AP2A_HUMAN
    • AP2TF
    • BOFS
    • FLJ51761
    • TFAP 2
    • TFAP 2A
    • TFAP2
    • TFAP2A
    • Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha)
    • Transcription factor AP-2-alpha
    • Transcription factor AP2 alpha
    see all
  • 機能Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.
  • 関連疾患Defects in TFAP2A are the cause of branchiooculofacial syndrome (BOFS) [MIM:113620]; also known as branchial clefts with characteristic facies, growth retardation, imperforate nasolacrimal duct, and premature aging or lip pseudocleft-hemangiomatous branchial cyst syndrome. BOFS is a rare autosomal dominant cleft palate craniofacial disorder with variable expressivity. The major features include cutaneous anomalies, ocular anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, renal and ectodermal (dental and hair) anomalies.
  • 配列類似性Belongs to the AP-2 family.
  • ドメインThe WW-binding motif mediates interaction with WWOX.
  • 翻訳後修飾Sumoylated on Lys-10; which inhibits transcriptional activity.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human AP2 alpha protein 画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human AP2 alpha protein (ab114726) 使用論文

ab114726 has not yet been referenced specifically in any publications.

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