製品の概要

  • 製品名
    Recombinant Human AMFR protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      QASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQV PFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLD
    • 分子量
      37 kDa including tags
    • 領域
      451 to 550

関連製品

特性

Our Abpromise guarantee covers the use of ab114887 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AMF receptor
    • AMF receptor isoform 1
    • AMF receptor isoform 2
    • AMFR
    • AMFR2_HUMAN
    • Autocrine motility factor receptor
    • Autocrine motility factor receptor precursor, isoform 1
    • Autocrine motility factor receptor precursor, isoform 2
    • E3 ubiquitin-protein ligase AMFR
    • gp78
    • isoform 2
    • RING finger protein 45
    • RNF 45
    • RNF45
    see all
  • 機能
    E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Contains 1 CUE domain.
    Contains 1 RING-type zinc finger.
  • 細胞内局在
    Endoplasmic reticulum membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114887 at approximately 36.63kDa.
    Stained with Coomassie Blue.

参考文献

ab114887 has not yet been referenced specifically in any publications.

レビューと Q&A

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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