Recombinant Human alpha Actinin 4 protein (ab126006)

製品の概要

  • 製品名Recombinant Human alpha Actinin 4 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号O43707
    • 生物種Human
    • 分子量29 kDa
    • 領域397 to 648

特性

Our Abpromise guarantee covers the use of ab126006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • actinin 4
    • Actinin alpha 4
    • actinin4
    • ACTN 4
    • ACTN4
    • ACTN4_HUMAN
    • Alpha-actinin-4
    • DKFZp686K23158
    • F actin cross linking protein
    • F-actin cross-linking protein
    • Focal segmental glomerulosclerosis 1
    • FSGS
    • FSGS 1
    • FSGS1
    • Non muscle alpha actinin 4
    • Non-muscle alpha-actinin 4
    see all
  • 機能F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
  • 組織特異性Widely expressed.
  • 関連疾患Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • 配列類似性Belongs to the alpha-actinin family.
    Contains 1 actin-binding domain.
    Contains 2 CH (calponin-homology) domains.
    Contains 2 EF-hand domains.
    Contains 4 spectrin repeats.
  • 細胞内局在Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines.
  • Information by UniProt

Recombinant Human alpha Actinin 4 protein (ab126006) 使用論文

ab126006 has not yet been referenced specifically in any publications.

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