製品の概要
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製品名Recombinant Human AKT2 protein
AKT2 タンパク質・ペプチド 製品一覧 -
タンパク質長Full length protein
法規制情報
製品の詳細
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由来Recombinant
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由来Baculovirus infected Sf9 cells
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アミノ酸配列
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アクセッション番号
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生物種Human
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分子量57 kDa
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タグHis tag N-Terminus
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab42593 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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生理活性Akt2 is inactive and can be activated by upstream kinase PDK1.
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アプリケーション
Inhibition Assay
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精製度> 90 % SDS-PAGE.
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製品の状態Liquid
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備考
Akt2 is inactive and can be activated by upstream kinase PDK1.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
関連情報
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別名
- Akt2
- AKT2_HUMAN
- HIHGHH
see all -
機能General protein kinase capable of phosphorylating several known proteins.
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組織特異性Expressed in all human cell types so far analyzed.
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配列類似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 PH domain.
Contains 1 protein kinase domain. -
翻訳後修飾Phosphorylation on Thr-309 and Ser-474 is required for full activity.
Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT2 ubiquitination. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. - Information by UniProt
参考文献
ab42593 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"