Recombinant human ADRB2 (CAM) + GsaL fusion protein (ab90773)

製品の概要

  • 製品名Recombinant human ADRB2 (CAM) + GsaL fusion protein
  • タンパク質長Full length protein
  • 製品の詳細
    Recombinant human ADRB2 (CAM) + GsαL fusion protein

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • 分子量104 kDa
    • 配列の追加情報Tagged at the N terminus of the ADRB2 with a DDDDK tag. The C terminus of the ADRB2 is linked to the N terminus of the Gs alpha L with a His tag.

特性

Our Abpromise guarantee covers the use of ab90773 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Activity: 2.4 - 4.9 pmol/mg
  • アプリケーション

    Functional Studies

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Adenylate cyclase stimulating G alpha protein
    • ADRB2
    • ADRB2R
    • ADRBR
    • Adrenergic beta 2 receptorsurface
    • AHO
    • B2AR
    • BAR
    • Beta 2 adrenergic receptor
    • Beta 2 adrenoceptor
    • BETA2AR
    • C20orf45
    • Catecholamine receptor
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide regulatory protein
    • MGC33735
    • NESP
    • PHP1A
    • PHP1B
    • POH
    see all
  • 関連性ADBR2 is a member of the G protein-coupled receptor superfamily. It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. ADBR2 receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADBR2CAM is a constitutively active mutant of the ADBR2. It differs from the wild-type receptor by four discrete amino acid substitutions in the third intracellular loop of the receptor L266 to S266, K267 to R267, H269 to K269, and L272 to A272). GsaL is the long splice variant of the alpha-subunit of the heterotrimeric G-protein Gs. Gs activates the effector adenylate cyclase. GsaL differs from the short splice variant by a 15 amino acid insert between the ras-like domain and the alpha-helical domain.
  • 細胞内局在ADRB2: Cell membrane; Multi-pass membrane protein.

Recombinant human ADRB2 (CAM) + GsaL fusion protein (ab90773) 使用論文

ab90773 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"